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Recombinant Human HABP2 Protein (His Tag)
Cat. No : CDRP-00108
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Target Information | |
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Target Name | HABP2 |
Synonyms | Hyaluronan-binding protein 2; Factor VII-activating protease; Factor seven-activating protease; Hepatocyte growth factor activator-like protein; Plasma hyaluronan-binding protein |
UniProt ID | P00738 |
Accession | Q14520 |
Product Details | |
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Expression Host | HEK293 Cells |
Species | Human |
Tag | C-6His |
Molar Mass | 36.2 kDa |
Sequence | Glu 23-Gly 375 |
Background |
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Hyaluronan-binding protein 2 (HABP2) is an extracellular serine protease which binds hyaluronic acid. It secreted as an inactive single-chain precursor and is then activated to a heterodimeric form, which consists of a 50 kDa heavy and a 27 kDa light chain linked by a disulfide bond. HABP2 is involved in cell adhesion, it can cleave the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' , but not the gamma-chain of fibrinogen. As a result of this, it does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator to the active two chain form, activates coagulation factor VII. |
Properties | |
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Purity | >90% as determined by reducing SDS-PAGE. |
Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months. |
! For research use only. Not intended for any clinical use.