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Recombinant Human FN14/TWEAKR Protein (Fc Tag)
Cat. No : CDRP-00057
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Target Information | |
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Target Name | FN14/TWEAKR |
Synonyms | CD266; FN14; TWEAKRTNFRSF12A; Fibroblast growth factor-inducible immediate-early response protein 14; FN14 |
UniProt ID | O43915 |
Accession | Q9NP84 |
Product Details | |
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Expression Host | HEK293 Cells |
Species | Human |
Tag | C-Fc |
Molar Mass | 35.6 kDa |
Sequence | Asp 22-Gln 118 |
Background |
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Tumor necrosis factor receptor superfamily member 12A(TNFRSF12A) is also known as Fibroblast growth factor-inducible immediate-early response protein 14, FN14, CD266 antigen and tweak-receptor. TNFRSF12A is a single-pass type I membrane protein, including a 27 aa signal peptide, a 53 aa extracellular domain, a 21 aa transmembrane domain and a 28 aa cytoplasmic domain. TNFRSF12A is highly expressed in heart, placenta and kidney. TNFRSF12A can be induced by FGF1 and phorbol ester. TNFRSF12A binds to TWEAK/TNFSF12A to initiate a signal transduction cascade, causing different cellular responses such as cell death, cell proliferation, and angiogenesis. |
Properties | |
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Purity | >90% as determined by reducing SDS-PAGE. |
Formulation | Lyophilized from a 0.2 μm filtered solution of 20 mM PBS, 150 mM NaCl, pH7.4. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months. |
! For research use only. Not intended for any clinical use.