Recombinant Human FN14/TWEAKR Protein (Fc Tag)
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Recombinant Human FN14/TWEAKR Protein (Fc Tag)

Cat. No : CDRP-00057
size:
Target Information
Target Name FN14/TWEAKR
Synonyms CD266; FN14; TWEAKRTNFRSF12A; Fibroblast growth factor-inducible immediate-early response protein 14; FN14
UniProt ID O43915
Accession Q9NP84
Product Details
Expression Host HEK293 Cells
Species Human
Tag C-Fc
Molar Mass 35.6 kDa
Sequence Asp 22-Gln 118
Background
Tumor necrosis factor receptor superfamily member 12A(TNFRSF12A) is also known as Fibroblast growth factor-inducible immediate-early response protein 14, FN14, CD266 antigen and tweak-receptor. TNFRSF12A is a single-pass type I membrane protein, including a 27 aa signal peptide, a 53 aa extracellular domain, a 21 aa transmembrane domain and a 28 aa cytoplasmic domain. TNFRSF12A is highly expressed in heart, placenta and kidney. TNFRSF12A can be induced by FGF1 and phorbol ester. TNFRSF12A binds to TWEAK/TNFSF12A to initiate a signal transduction cascade, causing different cellular responses such as cell death, cell proliferation, and angiogenesis.
Properties
Purity >90% as determined by reducing SDS-PAGE.
Formulation Lyophilized from a 0.2 μm filtered solution of 20 mM PBS, 150 mM NaCl, pH7.4.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months.

! For research use only. Not intended for any clinical use.