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Recombinant Human FABP3 Protein
Cat. No : CDRP-00320
size:
Target Information | |
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Target Name | FABP3 |
Synonyms | Fatty Acid-Binding Protein Heart; Fatty Acid-Binding Protein 3; Heart-Type Fatty Acid-Binding Protein; H-FABP; Mammary-Derived Growth Inhibitor; MDGIMuscle Fatty Acid-Binding Protein; M-FABP; FABP3; FABP11; MDGI; H-FABP; O-FABP |
UniProt ID | P07996 |
Accession | P05413 |
Product Details | |
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Expression Host | E.coli |
Species | Human |
Tag | None |
Molar Mass | 14.9 kDa |
Sequence | Met 1-Ala 771 |
Background |
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Fatty acid binding protein 3 (FABP3; also termed heart-type fatty acid binding protein) is a member of the intracellular lipid-binding protein family that may be essential in fatty acid transport; cell growth; cellular signaling and gene transcription. Previously FABP3 was involved in apoptosis-associated congenital cardiac malformations. FABP3 knockdown exhibited significant toxic effects on cardiac development and mitochondrial function; which may be responsible for the knockdown of FABP3-induced apoptosis. FABP3 as a candidate gene underlying the etiology of congenital heart defects. Overexpression of FABP3 inhibited cell growth and proliferation via negative regulation of the cell cycle and down-regulation of cell growth factors; but enhances cell survival in hypoxic or ischemic conditions. FABPs are known to be carrier proteins for transporting fatty acids and other lipophilic substances from the cytoplasm to the nucleus; where these lipids are released to a group of nuclear receptors such as peroxisome proliferator-activated receptors (PPARs). |
Properties | |
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Purity | >95% as determined by reducing SDS-PAGE. |
Formulation | Lyophilized from sterile 50 mM Tris, pH8.0. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months. |
! For research use only. Not intended for any clinical use.