Recombinant Human EphB1/EPHT2 Protein (aa 564-984, His Tag) (Active)

Cat. No : CDRP-00872

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Target Information
Target Name	EphB1/EPHT2
Synonyms	Ephrin Type-A Receptor 7; EPH Homology Kinase 3; EHK-3; EPH-Like Kinase 11; EK11; hEK11; EPHA7; EHK3; HEK11
UniProt ID	P63316
Accession	P54762

Product Details
Expression Host	HEK293 Cells
Species	Human
Tag	C-His
Molar Mass	48.8 kDa
Sequence	Gln 18-Gly 348
Application	Functional ELISA

Background
Ephrin Type-B Receptor 1 (EPHB1) is a single-pass type I membrane protein that belongs to the Ephrin-B family of receptor tyrosine kinases that is involved in embryonic nervous and vascular system development. EPHB1/EPHT2 contains two fibronectin type-III domains; one protein kinase domain and one SAM (sterile α motif) domain. EPHB1 could stimulate fibroblast motility on extracellular matrix in a kinase-dependent manner; which also correlated with its association with Grb7; an adaptor molecule implicated in the regulation of cell migration. It binds to ephrin-B1; ephrin-B2 and ephrin-B3. EPHB1 plays an important roles in diverse biological processes including nervous system development; angiogenesis; and neural synapsis formation and maturation and may be involved in cell-cell interactions in the nervous system.

Background

Ephrin Type-B Receptor 1 (EPHB1) is a single-pass type I membrane protein that belongs to the Ephrin-B family of receptor tyrosine kinases that is involved in embryonic nervous and vascular system development. EPHB1/EPHT2 contains two fibronectin type-III domains; one protein kinase domain and one SAM (sterile α motif) domain. EPHB1 could stimulate fibroblast motility on extracellular matrix in a kinase-dependent manner; which also correlated with its association with Grb7; an adaptor molecule implicated in the regulation of cell migration. It binds to ephrin-B1; ephrin-B2 and ephrin-B3. EPHB1 plays an important roles in diverse biological processes including nervous system development; angiogenesis; and neural synapsis formation and maturation and may be involved in cell-cell interactions in the nervous system.

Properties
Purity	>90% as determined by reducing SDS-PAGE.
Formulation	Lyophilized from a 0.2 μm filtered solution of 20 mM Tris, 150 mM NaCl, pH8.0.
Reconstitution	Please refer to the printed manual for detailed information.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months.

! For research use only. Not intended for any clinical use.