Recombinant Human EphA2 Protein (aa 585-976, GST & His Tag) (Active)
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Recombinant Human EphA2 Protein (aa 585-976, GST & His Tag) (Active)

Cat. No : CDRP-00687
size:
Target Information
Target Name EphA2
Synonyms Ephrin type-A receptor 2; Epithelial cell kinase; Tyrosine-protein kinase receptor ECK; EPHA2; ARCC2; CTPA; CTPP1; CTRCT6; ECK
UniProt ID P31415
Accession P29317
Product Details
Expression Host Baculovirus-Insect Cells
Species Human
Tag N-His-GST
Molar Mass 72.1 kDa
Sequence Tyr 4-Gln 210
Background
Eph receptor A2 (Ephrin type-A receptor 2 or EphA2) is a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. The Eph receptors' corresponding family of ligands are the ephrins anchored to cell surfaces. The ephrins and Eph receptors are implicated as positional labels that may guide the development of neural topographic maps. They have also been found implicated in embryonic patterning; neuronal targeting; vascular development and adult neovascularization. The large family of ligands and receptors may make a major contribution to the accurate spatial patterning of connections and cell position in the nervous system. Furthermore; elevated expression of Eph receptors and ephrin ligands is associated with tumors and associated tumor vasculature; suggesting the Eph receptors and ephrin ligands also play critical roles in tumor angiogenesis and tumor growth. Unlike most Eph kinases; which are primarily expressed during development; EphA2 is primarily found in adult human epithelial cells. The cellular functions of EphA2 may be regulating cell growth; survival; migration; and angiogenesis. Unlike other receptor tyrosine kinases; ligand binding is not necessary for EphA2. Rather; the ligand appears to regulate EphA2 subcellular localization and its interactions with downstream adapter and signaling proteins. Eph receptor A2(EphA2) has been demonstrated to critically regulate tumor cell growth; migration and invasiveness. Eph receptor A2(EphA2) is frequently overexpressed and functionally altered in aggressive tumor cells; and that these changes promote metastatic character.
Properties
Purity >98% as determined by reducing SDS-PAGE.
Formulation Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, 3 mM DTT, pH8.5.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.
Storage Store at < -20 °C, stable for 6 months. Please minimize freeze-thaw cycles.

! For research use only. Not intended for any clinical use.