Recombinant Human EPCR Protein (His Tag)

Cat. No : CDRP-01290

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Target Information
Target Name	EPCR
Synonyms	Endothelial Protein C Receptor; Activated Protein C Receptor; APC Receptor; Endothelial Cell Protein C Receptor; CD201; PROCR; EPCR
Accession	Q9UNN8

Product Details
Expression Host	HEK293 Cells
Species	Human
Tag	C-His
Molar Mass	23.4 kDa

Background
Endothelial protein C receptor (EPCR); also known as activated protein C receptor (APC receptor) or PROCR; is a receptor for Protein C. Protein C plays an important role in many metabolism processes in humans and other animals after activated by binding to Endothelial protein C receptor (EPCR). Because of the EPCR is found primarily on endothelial cells (cells on the inside of blood vessels); activated protein C is found maily near endothelial cells. Protein C is pleiotropic; with two main functions: anticoagulation and cytoprotection. Which function will be performed depend on whether or not protein C remains bind to EPCR after activated. The anticoagulation occurs when it does not. In this case; protein C functions as an anticoagulant by irreversibly proteolytically inactivating Factor Va and Factor VIIIa; turning them into Factor Vi and Factor VIIIi respectively. When still bound to EPCR; activated protein C performs its cytoprotective effects; acting on the effector substrate PAR-1; protease-activated receptor-1. To a degree; APC's anticoagulant properties are independent of its cytoprotective ones; in that expression of one pathway is not affected by the existence of the other.

Background

Endothelial protein C receptor (EPCR); also known as activated protein C receptor (APC receptor) or PROCR; is a receptor for Protein C. Protein C plays an important role in many metabolism processes in humans and other animals after activated by binding to Endothelial protein C receptor (EPCR). Because of the EPCR is found primarily on endothelial cells (cells on the inside of blood vessels); activated protein C is found maily near endothelial cells. Protein C is pleiotropic; with two main functions: anticoagulation and cytoprotection. Which function will be performed depend on whether or not protein C remains bind to EPCR after activated. The anticoagulation occurs when it does not. In this case; protein C functions as an anticoagulant by irreversibly proteolytically inactivating Factor Va and Factor VIIIa; turning them into Factor Vi and Factor VIIIi respectively. When still bound to EPCR; activated protein C performs its cytoprotective effects; acting on the effector substrate PAR-1; protease-activated receptor-1. To a degree; APC's anticoagulant properties are independent of its cytoprotective ones; in that expression of one pathway is not affected by the existence of the other.

Properties
Purity	>95% as determined by reducing SDS-PAGE.
Formulation	Lyophilized from sterile PBS, pH7.4.
Reconstitution	Please refer to the printed manual for detailed information.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months.

! For research use only. Not intended for any clinical use.