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Recombinant Human Endoglin/CD105 Protein (His & Trx Tag)
Cat. No : CDRP-00568
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Target Information | |
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Target Name | Endoglin/CD105 |
Synonyms | Endoglin; END; CD105; ENG; HHT1; ORW1 |
UniProt ID | P20333 |
Accession | P17813-1 |
Product Details | |
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Expression Host | E.coli |
Species | Human |
Tag | N-Trx-His |
Molar Mass | 33.6 kDa |
Sequence | Ser 112-Ile 270 |
Background |
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Endoglin is a single-pass type I membrane protein which restricted to endothelial cells in all tissues except bone marrow. Endoglin as major glycoprotein of vascular endothelium, it has been found on endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. Furthermore, Homodimer forms a heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It may have an important role in the binding of endothelial cells to integrins and/or other RGD receptors. Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1), which is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations. |
Properties | |
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Purity | >97% as determined by reducing SDS-PAGE. |
Formulation | Supplied as a 0.2 μm filtered solution of 20 mM PBS,150 mM NaCl, pH7.4. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. |
Storage | Store at < -20 °C, stable for 6 months. Please minimize freeze-thaw cycles. |
! For research use only. Not intended for any clinical use.