Recombinant Human DYRK3/REDK Protein (GST & His Tag) (Active)
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Recombinant Human DYRK3/REDK Protein (GST & His Tag) (Active)

Cat. No : CDRP-00088
size:
Target Information
Target Name DYRK3/REDK
Synonyms DYRK5; hYAK3-2; RED; REDK
UniProt ID O95445
Accession O43781-1
Product Details
Expression Host Baculovirus-Insect Cells
Species Human
Tag N-His & GST
Molar Mass 93.5 kDa
Sequence Trp 42-Ala 709
Background
Dual specificity tyrosine-phosphorylation-regulated kinase 3, also known as Regulatory erythroid kinase, REDK and DYRK3, is a nucleus protein which belongs to theprotein kinase superfamily, CMGC Ser/Thr protein kinase family and MNB/DYRK subfamily. DYRKs are an emerging family of dual-specificity kinases that play key roles in cell proliferation, survival, and development. DYRK3 contains oneprotein kinase domain. Isoform 1 and isoform 2 of DYRK3 are highly expressed in testis and in hematopoietic tissue such as fetal liver, and bone marrow. Isoform 2 of DYRK3 is the predominant form in testis. Isoform 1 of DYRK3 is the predominant form in fetal liver and bone marrow. Isoform 1 and isoform 2 are present at low levels in heart, pancreas, lymph node, and thymus. DYRK3 is a negative regulator of EPO-dependent erythropoiesis. It may place an upper limit on red cell production during stress erythropoiesis. DYRK3 inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. It may also act by regulating CREB/CRE signaling. DYRK3 proved to effectively inhibit NFAT (nuclear factor of activated T cells) transcriptional response pathways and to co-immunoprecipitate with NFATc3. DYRK3 attenuates (and possibly apportions) red cell production selectively during anemia.
Properties
Purity >98% as determined by reducing SDS-PAGE.
Formulation Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, 0.5 mM PMSF, 10% Glycerol, pH8.0.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.
Storage Store at < -20 °C, stable for 6 months. Please minimize freeze-thaw cycles.

! For research use only. Not intended for any clinical use.