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Recombinant Human DKK1/Dkk-1 Protein (His Tag)
Cat. No : CDRP-00114
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Target Information | |
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Target Name | DKK1/Dkk-1 |
Synonyms | Dickkopf-related protein 1; Dickkopf-1; Dkk-1; SK |
UniProt ID | P00750 |
Accession | O94907 |
Product Details | |
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Expression Host | HEK293 Cells |
Species | Human |
Tag | N-His |
Molar Mass | 27 kDa |
Sequence | Glu 31-Arg 370 |
Background |
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Dickkopf-related protein 1(DKK-1), is a member of the dickkopf family. DKK1 secreted proteins with two cysteine-rich domains separated by a linker region. It antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. |
Properties | |
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Purity | >92% as determined by reducing SDS-PAGE. |
Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months. |
! For research use only. Not intended for any clinical use.