Recombinant Human DKK1/Dkk-1 Protein (His Tag)
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Recombinant Human DKK1/Dkk-1 Protein (His Tag)

Cat. No : CDRP-00114
size:
Target Information
Target Name DKK1/Dkk-1
Synonyms Dickkopf-related protein 1; Dickkopf-1; Dkk-1; SK
UniProt ID P00750
Accession O94907
Product Details
Expression Host HEK293 Cells
Species Human
Tag N-His
Molar Mass 27 kDa
Sequence Glu 31-Arg 370
Background
Dickkopf-related protein 1(DKK-1), is a member of the dickkopf family. DKK1 secreted proteins with two cysteine-rich domains separated by a linker region. It antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Properties
Purity >92% as determined by reducing SDS-PAGE.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months.

! For research use only. Not intended for any clinical use.