Recombinant Human DDR2 Kinase/CD167b Protein (aa 422-855, GST & His Tag) (Active)
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Recombinant Human DDR2 Kinase/CD167b Protein (aa 422-855, GST & His Tag) (Active)

Cat. No : CDRP-01060
size:
Target Information
Target Name DDR2 Kinase/CD167b
Synonyms Discoidin domain-containing receptor 2; Discoidin domain receptor 2; CD167 antigen-like family member B; Neurotrophic tyrosine kinase; receptor-related 3; Receptor protein-tyrosine kinase TKT; Tyrosine-protein kinase TYRO10; CD167b; Ddr2; Ntrkr3; tyro10
UniProt ID Q64299
Accession Q16832
Product Details
Expression Host Baculovirus-Insect Cells
Species Human
Tag N-His & GST
Molar Mass 77.1 kDa
Sequence Tyr 58-Asn 141
Background
Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2, up-regulates matrix metallloproteinase 1 (MMP-1) and MMP-2 expression in cellular matrix. DDR2/CD167b was found to recognise the triple-helical region of collagen X as well as the NC1 domain. Binding to the collagenous region was dependent on the triple-helical conformation. DDR2/CD167b autophosphorylation was induced by the collagen X triple-helical region but not the NC1 domain, indicating that the triple-helical region of collagen X contains a specific DDR2 binding site that is capable of receptor activation. DDR2/CD167b is induced during stellate cell activation and implicate the phosphorylated receptor as a mediator of MMP-2 release and growth stimulation in response to type I collagen. Moreover, type I collagen-dependent upregulation of DDR2/CD167b expression establishes a positive feedback loop in activated stellate cells, leading to further proliferation and enhanced invasive activity.
Properties
Purity >98% as determined by reducing SDS-PAGE.
Formulation Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, pH7.4.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.
Storage Store at < -20 °C, stable for 6 months. Please minimize freeze-thaw cycles.

! For research use only. Not intended for any clinical use.