Recombinant Human Cytochrome C/CYCS Protein (His Tag)
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Recombinant Human Cytochrome C/CYCS Protein (His Tag)

Cat. No : CDRP-00928
size:
Target Information
Target Name Cytochrome C/CYCS
Synonyms Cytochrome C; CYCS; CYC
UniProt ID Q03591
Accession P99999
Product Details
Expression Host E.coli
Species Human
Tag C-6His
Molar Mass 12.8 kDa
Sequence Ser 17-Thr 206
Background
Cytochrome C (CYCS) is a small heme protein that belongs to the cytochrome c family. It is found loosely associated with the inner membrane of the mitochondrion. Cytochrome C is a highly soluble protein that functions as a central component of the electron transport chain in mitochondria. CYCS transfers electrons between Complexes III (Coenzyme Q - Cyt C reductase) and IV (Cyt C oxidase). CYCS plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of Cytochrome C to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
Properties
Purity >97% as determined by reducing SDS-PAGE.
Formulation Supplied as a 0.2 μm filtered solution of 20 mM Tris, 0.15M NaCl, 20% Glycerol, pH8.0.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.
Storage Store at < -20 °C, stable for 6 months. Please minimize freeze-thaw cycles.

! For research use only. Not intended for any clinical use.