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Recombinant Human Cytochrome C/CYCS Protein (His Tag)
Cat. No : CDRP-00928
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Target Information | |
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Target Name | Cytochrome C/CYCS |
Synonyms | Cytochrome C; CYCS; CYC |
UniProt ID | Q03591 |
Accession | P99999 |
Product Details | |
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Expression Host | E.coli |
Species | Human |
Tag | C-6His |
Molar Mass | 12.8 kDa |
Sequence | Ser 17-Thr 206 |
Background |
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Cytochrome C (CYCS) is a small heme protein that belongs to the cytochrome c family. It is found loosely associated with the inner membrane of the mitochondrion. Cytochrome C is a highly soluble protein that functions as a central component of the electron transport chain in mitochondria. CYCS transfers electrons between Complexes III (Coenzyme Q - Cyt C reductase) and IV (Cyt C oxidase). CYCS plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of Cytochrome C to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. |
Properties | |
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Purity | >97% as determined by reducing SDS-PAGE. |
Formulation | Supplied as a 0.2 μm filtered solution of 20 mM Tris, 0.15M NaCl, 20% Glycerol, pH8.0. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. |
Storage | Store at < -20 °C, stable for 6 months. Please minimize freeze-thaw cycles. |
! For research use only. Not intended for any clinical use.