Recombinant Human CRHBP Protein (His Tag)
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Recombinant Human CRHBP Protein (His Tag)

Cat. No : CDRP-00651
size:
Target Information
Target Name CRHBP
Synonyms Corticotropin-Releasing Factor-Binding Protein; CRF-BP; CRF-Binding Protein; Corticotropin-Releasing Hormone-Binding Protein; CRH-BP; CRHBP; CRFBP
UniProt ID P29279
Accession P24387
Product Details
Expression Host HEK293 Cells
Species Human
Tag C-6His
Molar Mass 34.4 kDa
Sequence Gln 22-Glu 259
Background
Corticotropin-Releasing Factor-Binding Protein (CRHBP) is a 37 kDa secreted glycoprotein that binds both CRH and urocortin in a 42 kDa extracellular complex. The molecule is approximately 300 amino acids in length and demonstrates five intrachain disulfide bonds. Difference between CRHBP from different species exist, human CRHBP is found in plasma while rodent and sheep CRHBP is limited to neuroendocrine tissues. CRHBP may inactivate CRH and may prevent inappropriate pituitary-adrenal stimulation in pregnancy. CRHBP is presumed to either sequester CRH, rendering it unavailable to cells or transport it to target tissues. Although CRF-BP concentration in the human peripheral circulation is normally low, it increases throughout pregnancy and fall back rapidly after parturition.
Properties
Purity >90% as determined by reducing SDS-PAGE.
Formulation Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH7.5.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months.

! For research use only. Not intended for any clinical use.