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Recombinant Human CMA1/Chymase 1 Protein (His Tag)
Cat. No : CDRP-00649
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Target Information | |
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Target Name | CMA1/Chymase 1 |
Synonyms | chymase; CYH; MCT1 |
UniProt ID | P29279 |
Accession | P23946 |
Product Details | |
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Expression Host | Baculovirus-Insect Cells |
Species | Human |
Tag | C-His |
Molar Mass | 26.6 kDa |
Sequence | Tyr 29-Trp 97 |
Background |
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Chymotrypsin C (abbreviated for CTRC), also known as caldecrin or elastase4, is a digestive enzyme of the peptidase S1 family. This enzyme is synthesized as an inactivate chymotrypsinogen. On cleavage by trypsin into two parts that activate each other by removing two small peptides in a trans-proteolysis, chymotrypsin C produced. N-linked glycosylation of human CTRC is required for efficient folding and secretion, however, the N-linked glycan is unimportant for enzyme activity or inhibitor binding. It has been proposed that CTRC is a key regulator of digestive zymogen activation and a physiological co-activator of digestive carboxypeptidases proCPA1 and proCPA2. Mutations that abolish activity or secretion of CTRC increase the risk for chronic pancreatitis. It's speculated that CTRC might regulate pancreatic cancer cell migration in relation to cytokeratin 18 expression. The pancreatic cancer cell migration ability was downregulated in pancreatic cancer Aspc-1 cells that overexpressed CTRC, whereas the cell migration ability was upregulated in Aspc-1 cells in which CTRC was suppressed. |
Properties | |
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Purity | >98% as determined by reducing SDS-PAGE. |
Formulation | Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, pH7.4. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. |
Storage | Store at < -20 °C, stable for 6 months. Please minimize freeze-thaw cycles. |
! For research use only. Not intended for any clinical use.