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Recombinant Human CD147/Basigin Protein
Cat. No : CDRP-01359
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Target Information | |
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Target Name | CD147/Basigin |
Synonyms | Basigin; 5F7; Collagenase Stimulatory Factor; Extracellular Matrix Metalloproteinase Inducer; EMMPRIN; Leukocyte Activation Antigen M6; OK Blood Group Antigen; Tumor Cell-Derived Collagenase Stimulatory Factor; TCSF; CD147; BSG |
Accession | NP_940991.1 |
Product Details | |
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Expression Host | HEK293 Cells |
Species | Human |
Tag | None |
Molar Mass | 20.7 kDa |
Sequence | Met 1-Ala 423 |
Background |
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CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer); also known as Basigin (BSG); is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. It is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis; embryo implantation; neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells; and thereby promotes invasion; metastasis; growth and survival of malignant cells. Furthermore; CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. Recently; CD147 displays increased expression in many cancers; and it has been previously demonstrated to participate in cancer metastasis and progression. Thus; CD147 and its antibody are used as an effective treatment for malignant cancers. |
Properties | |
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Purity | >95% as determined by reducing SDS-PAGE. |
Formulation | Lyophilized from sterile 50 mM Tris, 100 mM NaCl, pH8.0. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months. |
! For research use only. Not intended for any clinical use.