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Recombinant Human Carboxylesterase 1/CES1 Protein (His Tag)
Cat. No : CDRP-00636
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Target Information | |
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Target Name | Carboxylesterase 1/CES1 |
Synonyms | Liver Carboxylesterase 1; Acyl-Coenzyme A:Cholesterol Acyltransferase; ACAT; Brain Carboxylesterase hBr1; Carboxylesterase 1; CE-1; hCE-1; Cocaine Carboxylesterase; Egasyn; HMSE; Methylumbelliferyl-Acetate Deacetylase 1; Monocyte/Macrophage Serine Esterase; Retinyl Ester Hydrolase; REH; Serine Esterase 1; Triacylglycerol Hydrolase; TGH; CES1; CES2; SES1 |
UniProt ID | P27658 |
Accession | P23141-3 |
Product Details | |
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Expression Host | HEK293 Cells |
Species | Human |
Tag | C-6His |
Molar Mass | 61.1 kDa |
Sequence | Pro 63-Gln 256 |
Background |
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Carboxylesterase 1 (CES1) is a member of a large family of carboxylesterases that are responsible for the hydrolysis of ester and amide bonds. These enzymes have broad substrate specificity ranging from small molecule esters such as phenylester to long chain fatty acid esters and thioesters. They are major determinants of the pharmacokinetic behavior of most therapeutic agents containing an ester or amide bond. CES1 shares the serine hydrolase fold observed in other esterases. CES1 hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. CES1 participates in detoxification of drugs such as cocaine and heroin in serum and liver. It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds. |
Properties | |
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Purity | >96% as determined by reducing SDS-PAGE. |
Formulation | Supplied as a 0.2 μm filtered solution of 20 mM HAc-NaAc, 150 mM NaCl, pH4.0. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. |
Storage | Store at < -20 °C, stable for 6 months. Please minimize freeze-thaw cycles. |
! For research use only. Not intended for any clinical use.