Recombinant Human CAMK1/CaMKI-alpha Protein
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Recombinant Human CAMK1/CaMKI-alpha Protein

Cat. No : CDRP-01346
size:
Target Information
Target Name CAMK1/CaMKI-alpha
Synonyms Calcium/Calmodulin-Dependent Protein Kinase Type 1; CaM Kinase I; CaM-KI; CaM Kinase I Alpha; CaMKI-Alpha; CAMK1
Accession NP_003647.1
Product Details
Expression Host E.coli
Species Human
Tag None
Molar Mass 41.5 kDa
Sequence Met 1-Ala 212
Background
Calcium/calmodulin-dependent protein kinase orCaM kinases are serine/threonine-specific protein kinasesthat are primarily regulated by the Calcium/calmodulin complex. These kinases show a memory effect on activation. CaM kinases activity can outlast the intracellular calcium transient that is needed to activate it. Inneurons, this property is important for the induction of synaptic plasticity. Pharmacological inhibition of CaM kinases II blocks the induction oflong-term potentiation. Upon activation, CaM kinases II phosphorylates postsynaptic glutamate receptors and changes the electrical properties of the synapse. Calcium/calmodulin-dependent protein kinase type 1D, also known as CaM kinase I delta, CaM kinase ID, CaMKI-like protein kinase, CKLiK and CAMK1D, is a member of theprotein kinase superfamily and CaMK subfamily. It contains oneprotein kinase domain. CAMK1D is broadly expressed. It is highly and mostly expressed in polymorphonuclear leukocytes (neutrophilic and eosinophilic granulocytes) while little or no expression is observed in monocytes and lymphocytes. Engineered overexpression of CAMK1D in non-tumorigenic breast epithelial cells led to increased cell proliferation, and molecular and phenotypic alterations indicative of epithelial-mesenchymal transition (EMT), including loss of cell-cell adhesions and increased cell migration and invasion. CAMK1D is a potential therapeutic target with particular relevance to clinically unfavorable basal-like tumors.
Properties
Purity >95% as determined by reducing SDS-PAGE.
Formulation Lyophilized from sterile 50 mM Tirs, 150 mM NaCl, 10% Glycerol, pH7.5.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months.

! For research use only. Not intended for any clinical use.