Recombinant Human CALCB Protein (aa 1-118, Fc Tag)

Cat. No : CDRP-00424

size:

Target Information
Target Name	CALCB
Synonyms	Calcitonin gene-related peptide 2; CALC2; Beta-type CGRP; Calcitonin gene-related peptide II; CALCB
UniProt ID	P12032
Accession	P10092

Product Details
Expression Host	HEK293 Cells
Species	Human
Tag	C-mFc
Molar Mass	36.2 kDa
Sequence	Met 1-Thr 290

Background
CALCB; also known as CGPR and calcitonin 2; belongs to the calcitonin family. CALCB is a calcitonin (CT) peptide which may play a role in the mediation of human inflammatory diseases. It is highly expressed in the skin; blood; and cerebrospinal fluid. CGRP immunolabeling (IL) was detected in epidermal keratinocytes at levels that were especially high and widespread in the skin of humans from locations afflicted with postherpetic neuralgia (PHN) and complex region pain syndrome type 1 (CRPS); of monkeys infected with simian immunodeficiency virus; and of rats subjected to L5/L6 spinal nerve ligation; sciatic nerve chronic constriction; and subcutaneous injection of complete Freund's adjuvant. Increased CGRP-IL was also detected in epidermal keratinocytes of transgenic mice with keratin-14 promoter driven overexpression of noggin; an antagonist to BMP-4 signaling. CGPR dilates a variety of vessels including the coronary; cerebral and systemic vasculature.

Background

CALCB; also known as CGPR and calcitonin 2; belongs to the calcitonin family. CALCB is a calcitonin (CT) peptide which may play a role in the mediation of human inflammatory diseases. It is highly expressed in the skin; blood; and cerebrospinal fluid. CGRP immunolabeling (IL) was detected in epidermal keratinocytes at levels that were especially high and widespread in the skin of humans from locations afflicted with postherpetic neuralgia (PHN) and complex region pain syndrome type 1 (CRPS); of monkeys infected with simian immunodeficiency virus; and of rats subjected to L5/L6 spinal nerve ligation; sciatic nerve chronic constriction; and subcutaneous injection of complete Freund's adjuvant. Increased CGRP-IL was also detected in epidermal keratinocytes of transgenic mice with keratin-14 promoter driven overexpression of noggin; an antagonist to BMP-4 signaling. CGPR dilates a variety of vessels including the coronary; cerebral and systemic vasculature.

Properties
Purity	>95% as determined by reducing SDS-PAGE.
Formulation	Lyophilized from sterile PBS, pH7.4.
Reconstitution	Please refer to the printed manual for detailed information.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months.

! For research use only. Not intended for any clinical use.