Recombinant Human Autotaxin/ENPP2 Protein (aa 36-863, His Tag)
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Recombinant Human Autotaxin/ENPP2 Protein (aa 36-863, His Tag)

Cat. No : CDRP-01011
size:
Target Information
Target Name Autotaxin/ENPP2
Synonyms ATX; E-NPP 2; lysoPLD; Npps2; PD-Ialpha; Pdnp2
UniProt ID Q15389
Accession Q13822
Product Details
Expression Host HEK293 Cells
Species Human
Tag C-His
Molar Mass 90 kDa
Sequence Gln 25-Pro 147
Background
ENPP-2, also known as Autotaxin, belongs to the ectonucleotide pyrophosphatase/phosphodiesterase (NPP) family. Some NPPs hydrolyze phosphates from nucleotides and their derivatives. ENPP-2 shares 40 - 50% identity to ENPP1 & 3, all of which contain a N-terminal intracellular domain, a single transmembrane domain and a large extracellular domain that includes a catalytic domain, two somatomedin-B-like domains, and a C-terminal nuclease-like domain. Evidence shows LPA and sphingosine 1-phosphate to be specific inhibitors of ENPP-2. ENPP-2 was originally found to stimulate tumor cell motility and has since been found to enhance tumor invasion and metastasis and to be up-regulated in several types of carcinomas including breast and lung.
Properties
Purity >90% as determined by reducing SDS-PAGE.
Formulation Lyophilized from a 0.2 μm filtered solution of 20 mMPBS, 150 mMNaCl, pH7.4.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months.

! For research use only. Not intended for any clinical use.