Products
Online Inquiry
Recombinant Human Autotaxin/ENPP2 Protein (aa 36-863, His Tag)
Cat. No : CDRP-01011
size:
Target Information | |
---|---|
Target Name | Autotaxin/ENPP2 |
Synonyms | ATX; E-NPP 2; lysoPLD; Npps2; PD-Ialpha; Pdnp2 |
UniProt ID | Q15389 |
Accession | Q13822 |
Product Details | |
---|---|
Expression Host | HEK293 Cells |
Species | Human |
Tag | C-His |
Molar Mass | 90 kDa |
Sequence | Gln 25-Pro 147 |
Background |
---|
ENPP-2, also known as Autotaxin, belongs to the ectonucleotide pyrophosphatase/phosphodiesterase (NPP) family. Some NPPs hydrolyze phosphates from nucleotides and their derivatives. ENPP-2 shares 40 - 50% identity to ENPP1 & 3, all of which contain a N-terminal intracellular domain, a single transmembrane domain and a large extracellular domain that includes a catalytic domain, two somatomedin-B-like domains, and a C-terminal nuclease-like domain. Evidence shows LPA and sphingosine 1-phosphate to be specific inhibitors of ENPP-2. ENPP-2 was originally found to stimulate tumor cell motility and has since been found to enhance tumor invasion and metastasis and to be up-regulated in several types of carcinomas including breast and lung. |
Properties | |
---|---|
Purity | >90% as determined by reducing SDS-PAGE. |
Formulation | Lyophilized from a 0.2 μm filtered solution of 20 mMPBS, 150 mMNaCl, pH7.4. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months. |
! For research use only. Not intended for any clinical use.