Recombinant Human ATG4A Protein (His Tag)

Cat. No : CDRP-01154

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Target Information
Target Name	ATG4A
Synonyms	Cysteine Protease ATG4A; AUT-Like 2 Cysteine Endopeptidase; Autophagin-2; Autophagy-Related Cysteine Endopeptidase 2; Autophagy-Related Protein 4 Homolog A; hAPG4A; ATG4A; APG4A; AUTL2
UniProt ID	Q99988
Accession	Q8WYN0

Product Details
Expression Host	E.coli
Species	Human
Tag	N-6His
Molar Mass	47.5 kDa
Sequence	Ser 2-Pro 531

Background
Cysteine Protease ATG4A (ATG4A) is a cytoplasmic protein that belongs to the peptidase C54 family. ATG4A is widely expressed in many tissues at a low level, but the highest expression is observed in skeletal muscle and brain. ATG4A is a cysteine protease required for autophagy; it cleaves the C-terminal part of MAP1LC3, GABARAPL2 or GABARAP. ATG4A is inhibited by N-ethylmaleimide. It is suggested that ATG4A has a significant role in suppressing various cancers.

Background

Cysteine Protease ATG4A (ATG4A) is a cytoplasmic protein that belongs to the peptidase C54 family. ATG4A is widely expressed in many tissues at a low level, but the highest expression is observed in skeletal muscle and brain. ATG4A is a cysteine protease required for autophagy; it cleaves the C-terminal part of MAP1LC3, GABARAPL2 or GABARAP. ATG4A is inhibited by N-ethylmaleimide. It is suggested that ATG4A has a significant role in suppressing various cancers.

Properties
Purity	>97% as determined by reducing SDS-PAGE.
Formulation	Supplied as a 0.2 μm filtered solution of 20 mM PBS, 150 mM NaCl, pH7.4.
Reconstitution	Please refer to the printed manual for detailed information.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.
Storage	Store at < -20 °C, stable for 6 months. Please minimize freeze-thaw cycles.

! For research use only. Not intended for any clinical use.