Recombinant Human APOM Protein (Fc Tag)

Cat. No : CDRP-00121

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Target Information
Target Name	APOM
Synonyms	Apolipoprotein M; Apo-M; ApoM; Protein G3a; APOM; G3A; NG20
UniProt ID	P01008
Accession	O95445

Product Details
Expression Host	HEK293 Cells
Species	Human
Tag	C-hFc
Molar Mass	45.6 kDa
Sequence	Met 1-Val 367

Background
ApoM (apolipoprotein M) is an apolipoprotein and member of the lipocalin protein family. The lipocalins share limited regions of sequence homology and a common tertiary structure architecture. They have an eight-stranded; antiparallel; symmetrical _-barrel fold; which is in essence a beta sheet which has been rolled into a cylindrical shape. Inside this barrel is located a ligand binding site. They transport small hydrophobic molecules such as steroids; bilins; retinoids; and lipids. Lipocalins have been associated with many biological processes; among them immune response; pheromone transport; biological prostaglandin synthesis; retinoid binding; and cancer cell interactions. Lipocalins are comparatively small in size; and are thus less complicated to study as opposed to large; bulky proteins. They can also bind to various ligands for different biological purposes. ApoM is associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. ApoM is involved in lipid transport and can bind sphingosine-1-phosphate; myristic acid; palmitic acid and stearic acid; retinol; all-trans-retinoic acid and 9-cis-retinoic acid.

Background

ApoM (apolipoprotein M) is an apolipoprotein and member of the lipocalin protein family. The lipocalins share limited regions of sequence homology and a common tertiary structure architecture. They have an eight-stranded; antiparallel; symmetrical _-barrel fold; which is in essence a beta sheet which has been rolled into a cylindrical shape. Inside this barrel is located a ligand binding site. They transport small hydrophobic molecules such as steroids; bilins; retinoids; and lipids. Lipocalins have been associated with many biological processes; among them immune response; pheromone transport; biological prostaglandin synthesis; retinoid binding; and cancer cell interactions. Lipocalins are comparatively small in size; and are thus less complicated to study as opposed to large; bulky proteins. They can also bind to various ligands for different biological purposes. ApoM is associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. ApoM is involved in lipid transport and can bind sphingosine-1-phosphate; myristic acid; palmitic acid and stearic acid; retinol; all-trans-retinoic acid and 9-cis-retinoic acid.

Properties
Purity	>95% as determined by reducing SDS-PAGE.
Formulation	Lyophilized from sterile PBS, pH7.4.
Reconstitution	Please refer to the printed manual for detailed information.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months.

! For research use only. Not intended for any clinical use.