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Recombinant Human Angiogenin/ANG Protein
Cat. No : CDRP-00275
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| Target Information | |
|---|---|
| Target Name | Angiogenin/ANG |
| Synonyms | Angiogenin; Ribonuclease 5; RNase 5; ANG; RNASE5 |
| UniProt ID | P05160 |
| Accession | P03950 |
| Product Details | |
|---|---|
| Expression Host | E.coli |
| Species | Human |
| Tag | None |
| Molar Mass | 14.3 kDa |
| Sequence | Arg 319-Pro 589 |
| Background |
|---|
| Angiogenin belongs to the pancreatic ribonuclease family. Angiogenin is primarily expressed in the liver. It may act as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Angiogenin is a potent stimulator of new blood vessel formation. And Angiogenin is endocytosed and translocated to the nucleus by binding to actin on the surface of endothelial cells. Angiogenic activity is regulated by interaction with RNH1 in vivo. In addition, Angiogenin is associated with susceptibility to amyotrophic lateral sclerosis, which is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. |
| Properties | |
|---|---|
| Purity | >90% as determined by reducing SDS-PAGE. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20 mM PBS, 150 mM NaCl, pH7.4. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months. |
! For research use only. Not intended for any clinical use.