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Recombinant Human Afamin/AFM Protein (C-6His)
Cat. No : CDRP-00801
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Target Information | |
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Target Name | Afamin/AFM |
Synonyms | Afamin; AFM; ALB2; ALB2alpha-Alb; ALBA; ALBAalpha-albumin; ALF; Alpha-Alb; Alpha-albumin |
UniProt ID | P50231 |
Accession | P43652 |
Product Details | |
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Expression Host | HEK293 Cells |
Species | Human |
Tag | C-6His |
Molar Mass | 67.6 kDa |
Sequence | Glu 18-Asn 247 |
Background |
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Afamin also known as Alpha -Albumin is a secreted monomeric glycoprotein of the Alb/Albumin family of molecules. AFM is known to bind and transport vitamin E family molecules, playing an important role for transporting at the blood-brain-barrier. Afamin has been shown to act as extracellular chaperone for poorly soluble, acylated Wnt proteins, forming a stable, soluble complex with functioning Wnt proteins. AFM also serves as an osteoclast-derived chemoattractant for preosteoblasts, providing a rational for the observation that bone formation often follows bone resorption. The importance of Afamin in transport of molecules has led to a suggested diagnostic role in various diseases, including pre-eclampsia, ovarian cancer, and both gestational and type-2 diabetes. |
Properties | |
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Purity | >90% as determined by reducing SDS-PAGE. |
Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
Reconstitution | Please refer to the printed manual for detailed information. |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months. |
! For research use only. Not intended for any clinical use.