Recombinant Human ACOX1/aox Protein (His Tag)
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Recombinant Human ACOX1/aox Protein (His Tag)

Cat. No : CDRP-00002
size:
Target Information
Target Name ACOX1/aox
Synonyms ACOX; PALMCOX; SCOX
UniProt ID B8YI02
Accession AAH08767.1
Product Details
Expression Host Baculovirus-Insect Cells
Species Human
Tag N-His
Molar Mass 76.7 kDa
Sequence Lys 19-Pro 108
Background
Peroxisomal acyl-coenzyme A oxidase 1(ACOX1 or AOX) is the first enzyme of the fatty acid beta-oxidation pathway and belongs to the Acyl-CoA oxidase family. Human liver peroxisomes contain two acyl-CoA oxidases, namely, palmitoyl-CoA oxidase (ACOX1/AOX) and a branched chain acyl-CoA oxidase. The palmitoyl-CoA oxidase (ACOX1/AOX) oxidizes the CoA esters of straight chain fatty acids and prostaglandins and donates electrons directly to molecular oxygen, thereby producing H2O2. Human ACOX1/AOX is a protein of 661-amino acids, including the carboxyl-terminal sequence(Ser-Lys-Leu) known as a minimal peroxisome-targeting signal. Human ACOX1/AOX, the first and rate-limiting enzyme of the peroxisomal β-oxidation pathway, has two isoforms including ACOX1a and ACOX1b, transcribed from a single gene. The human ACOX1b isoform is more effective than the ACOX1a isoform in reversing the Acox1 null phenotype in the mouse partly because of the Substrate utilization differences.
Properties
Purity >95% as determined by reducing SDS-PAGE.
Formulation Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH7.0.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months.

! For research use only. Not intended for any clinical use.