Recombinant Human ACO1/irp1 Protein (His Tag)
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Recombinant Human ACO1/irp1 Protein (His Tag)

Cat. No : CDRP-00612
size:
Target Information
Target Name ACO1/irp1
Synonyms ACONS; HEL60; IREB1; IREBP; IREBP1; IRP1
UniProt ID P23560
Accession P21399
Product Details
Expression Host Baculovirus-Insect Cells
Species Human
Tag N-His
Molar Mass 101 kDa
Sequence Met 1-Ala 539
Background
Aconitase 1(ACO1) or IRP1 is one member of the aconitase family that contains a diverse group of iron-sulphur(Fe-S) isomerases and two types of iron regulatory protein. Aconitase exits in two forms: one is soluble and the other is mitochondrial. ACO1 is the soluble existing form, and the mitochondrial form is ACO2. Residues from all three N-terminal domains and the larger C-terminal domain contribute to the active site region. When the enzyme is activated, it gains an additional iron atom. ACO1 can assume two different functions in cells, depending on different conditions. During iron scarcity or oxidative stress, ACO1 binds to mRNA stem-loop structures called iron responsive elements to modulate the translation of iron metabolism genes. In iron-rich conditions, ACO1 binds an iron-sulfur cluster to function as a cytosolic aconitase.
Properties
Purity >95% as determined by reducing SDS-PAGE.
Formulation Lyophilized from sterile 50 mM Tris, 100 mM NaCl, pH8.0.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months.

! For research use only. Not intended for any clinical use.