PMX-53
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PMX-53

Cat. No: CDIA-0126
CAS. No.: 219639-75-5
Synonyms: 3D53
Size: 1 mg
Price: Inquiry
Product Details
Formula C47H65N11O7
Molecular Weight 896.09
Appearance Solid
Purity 98.07%
Sequence Shortening F-{Orn}-P-{d-Cha}-WR (Lactam bridge: Orn2- Arg6)
Storage & Handling
Shipping Room temperature.
Storage Sealed storage, away from moisture and light, under nitrogen *In solvent : -80 °C, 6 months; -20 °C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Storage Powder -80 °C/2 years, -20 °C/1 year

Description

PMX-53 (3D53) is a synthetic peptidic and a potent and orally active complement C5a receptor (CD88) antagonist with an IC50 of 20 nM. PMX-53 is also a low-affinity MrgX2 agonist that stimulates MrgX2-mediated mast cell degranulation. PMX-53 specifically binds to C5aR1 and does not bind to the second C5aR (C5L2) and C3aR. PMX-53 has anti-inflammatory, anticancer and antiatherosclerotic effects.

! For research use only. Not intended for any clinical use.