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PF-543 citrate

Cat. No: CDIA-0128

CAS. No.: 1415562-83-2

Synonyms: Sphingosine Kinase 1 Inhibitor II Citrate

Size: 1 mg

Price: Inquiry

Product Details
Formula	C33H39NO11S
Molecular Weight	657.73
Appearance	Solid
Purity	98.35%
Smiles String	OC(C(O)=O)(CC(O)=O)CC(O)=O.O=S(C1=CC=CC=C1)(CC2=CC(C)=CC(OCC3=CC=C(CN4[[email protected]@H](CO)CCC4)C=C3)=C2)=O

Storage & Handling
Shipping	Room temperature.
Storage	4 °C, sealed storage, away from moisture *In solvent : -80 °C, 6 months; -20 °C, 1 month (sealed storage, away from moisture)

Description

PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 Citrate is >100-fold selectivity for SPHK1 over SPHK2. PF-543 Citrate is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM. PF-543 Citrate induces apoptosis, necrosis, and autophagy.

! For research use only. Not intended for any clinical use.