Pactimibe sulfate
Cat. No: CDIA-0824
CAS. No.: 608510-47-0
Synonyms: CS-505
Size: 250 μg
Product Details |
Formula |
C25H40N2O3.1/2H2O4S |
Molecular Weight |
465.65 |
Appearance |
Solid |
Purity |
98.22% |
Smiles String |
O=C(O)CC1=C(C)C2=C(N(CCCCCCCC)CC2)C(NC(C(C)(C)C)=O)=C1C.O=S(O)(O)=O.[1/2] |
Storage & Handling |
Shipping |
Room temperature. |
Storage |
4 °C, sealed storage, away from moisture
*In solvent : -80 °C, 6 months; -20 °C, 1 month (sealed storage, away from moisture) |
Description
Pactimibe sulfate (CS-505) is a dual ACAT1/2 inhibitor with IC50s of 4.9 μM and 3.0 μM, respectively. Pactimibe sulfate (CS-505) inhibits ACAT with IC50s of 2.0 μM, 2.7 μM, 4.7 μM in the liver, macrophages and THP-1 cells, respectively. Pactimibe sulfate (CS-505) noncompetitively inhibits oleoyl-CoA with a Ki value of 5.6 μM. Moreover, Pactimibe sulfate (CS-505) obviously inhibits cholesteryl ester formation with an IC50 of 6.7 μM. Pactimibe sulfate (CS-505) possesses anti-atherosclerotic potential with lowering plasma cholesterol activity.
! For research use only. Not intended for any clinical use.
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