NKH477

Product Details
Formula	C27H44ClNO8
Molecular Weight	546.09
Appearance	Solid
Purity	≥98.0%
Smiles String	O[[email protected]@]12[[email protected]@]3([[email protected]@](C(C)(CC[[email protected]@H]3O)C)([H])[[email protected]](OC(CCN(C)C)=O)[[email protected]](OC(C)=O)[[email protected]]1(O[[email protected]](C=C)(C)CC2=O)C)C.Cl

Storage & Handling
Shipping	Room temperature.
Storage	-20 °C, protect from light, stored under nitrogen *The compound is unstable in solutions, freshly prepared is recommended.

NKH477 (Colforsin dapropate hydrochloride) directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 is a forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts.

! For research use only. Not intended for any clinical use.