NKH477
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NKH477

Cat. No: CDIA-0249
CAS. No.: 138605-00-2
Synonyms: Colforsin dapropate hydrochloride
Size: 1 mg
Price: Inquiry
Product Details
Formula C27H44ClNO8
Molecular Weight 546.09
Appearance Solid
Purity ≥98.0%
Smiles String O[[email protected]@]12[[email protected]@]3([[email protected]@](C(C)(CC[[email protected]@H]3O)C)([H])[[email protected]](OC(CCN(C)C)=O)[[email protected]](OC(C)=O)[[email protected]]1(O[[email protected]](C=C)(C)CC2=O)C)C.Cl
Storage & Handling
Shipping Room temperature.
Storage -20 °C, protect from light, stored under nitrogen *The compound is unstable in solutions, freshly prepared is recommended.

Description

NKH477 (Colforsin dapropate hydrochloride) directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 is a forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts.

! For research use only. Not intended for any clinical use.