NF449 octasodium
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NF449 octasodium

Cat. No: CDIA-0398
CAS. No.: 627034-85-9
Size: 1 mg
Price: Inquiry
Product Details
Formula C41H24N6Na8O29S8
Molecular Weight 1505.09
Appearance Solid
Purity ≥99.0%
Smiles String O=C(NC1=CC(C(NC2=CC=C(S(=O)(O[Na])=O)C=C2S(=O)(O[Na])=O)=O)=CC(C(NC3=CC=C(S(=O)(O[Na])=O)C=C3S(=O)(O[Na])=O)=O)=C1)NC4=CC(C(NC5=CC=C(S(=O)(O[Na])=O)C=C5S(=O)(O[Na])=O)=O)=CC(C(NC6=CC=C(S(=O)(O[Na])=O)C=C6S(=O)(O[Na])=O)=O)=C4
Storage & Handling
Shipping Room temperature.
Storage -20 °C, stored under nitrogen *In solvent : -80 °C, 6 months; -20 °C, 1 month (stored under nitrogen)

Description

NF449 octasodium is a highly potent P2X1 receptor antagonist, with IC50s of 0.28, 0.69, and 120 nM for rP2X1, rP2X1+5, P2X2+3, respectively. NF449 octasodium is a Gsα-selective G Protein antagonist. NF449 octasodium suppresses the rate of GTP[γS] binding to Gsα-s, inhibits the stimulation of adenylyl cyclase activity, and blocks the coupling of β-adrenergic receptors to Gs.

! For research use only. Not intended for any clinical use.