MK-0159

Product Details
Formula	C20H24N4O3S
Molecular Weight	400.49
Appearance	Solid
Purity	99.72%
Smiles String	O=C(C1=C2C(NC=C2)=NC(C3=CN=CS3)=C1)N[[email protected]]4CC[[email protected]](OCCOC)CC4

Storage & Handling
Shipping	Room temperature.
Storage	4 °C, sealed storage, away from moisture and light *In solvent : -80 °C, 6 months; -20 °C, 1 month (sealed storage, away from moisture and light)

MK-0159 (compound 37) is an orally active, potent and selective CD38 inhibitor, with IC50 values of 22, 3, and 70 nM for human, mouse and rat CD38, respectively. MK-0159 also shows good microsomal stability for human and rodent liver microsomes. MK-0159 increases NAD+ (nicotinamide adenine dinucleotide) and reduces ADPR (adenosine diphosphate ribose) in whole blood and heart.

! For research use only. Not intended for any clinical use.