Marein

Product Details
Formula	C21H22O11
Molecular Weight	450.39
Appearance	Solid
Purity	99.28%
Smiles String	O=C(C1=CC=C(O[[email protected]]2[[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]@H](CO)O2)O)O)O)C(O)=C1O)/C=C/C3=CC=C(O)C(O)=C3

Storage & Handling
Shipping	Room temperature.
Storage	4 °C, protect from light *In solvent : -80 °C, 6 months; -20 °C, 1 month (protect from light)

Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC50 of 100 µM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects.

! For research use only. Not intended for any clinical use.