M8891

Cat. No: CDIA-0642

CAS. No.: 1464842-09-8

Size: 5 mg

Price: Inquiry

Product Details
Formula	C20H17F2N3O3
Molecular Weight	385.36
Appearance	Solid
Purity	98.97%
Smiles String	O=C([[email protected]]1(O)C(N(C2=CC3=C(NC=C3)C=C2)CC1)=O)NCC4=CC(F)=CC(F)=C4

Storage & Handling
Shipping	Room temperature.
Storage	4 °C, protect from light *In solvent : -80 °C, 6 months; -20 °C, 1 month (protect from light)

Description

M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor with an IC50 of 54 nM and a Ki of 4.33 nM. M8891 does not inhibit MetAP-1 (IC50>10 µM). M8891 inhibits growth of primary endothelial cells as well as tumor cells and demonstrates antiangiogenic and antitumoral activity.

! For research use only. Not intended for any clinical use.