Losartan carboxylic acid
Cat. No: CDIA-0582
CAS. No.: 124750-92-1
Synonyms: E-3174; EXP-3174
Size: 5 mg
| Product Details |
| Formula |
C22H21ClN6O2 |
| Molecular Weight |
436.89 |
| Appearance |
Solid |
| Purity |
99.35% |
| Smiles String |
O=C(C1=C(Cl)N=C(CCCC)N1CC2=CC=C(C3=CC=CC=C3C4=NNN=N4)C=C2)O |
| Storage & Handling |
| Shipping |
Room temperature. |
| Storage Powder |
-20 °C/3 years, 4 °C/2 years |
Description
Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure.
! For research use only. Not intended for any clinical use.
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