ISX-9 (GMP)
Cat. No: CDIA-1345
CAS. No.: 832115-62-5
Synonyms: Isoxazole 9 (GMP)
Size: 50 mg
Product Details |
Formula |
C11H10N2O2S |
Molecular Weight |
234.27 |
Smiles String |
O=C(C1=NOC(C2=CC=CS2)=C1)NC3CC3 |
Storage & Handling |
Shipping |
Room temperature. |
Storage |
Please refer to the instruction manual. |
Description
ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation. ISX-9 activates Ca2+ influx through both voltage-gated Ca2+ channels and NMDA receptors and increases neuroD expression. ISX-9 also induces cardiomyogenic differentiation of Notch-activated epicardium-derived cells (NECs).
In Vitro: ISX-9 promotes neurogenesis in vivo, enhancing the proliferation and differentiation of hippocampal subgranular zone (SGZ) neuroblasts, and the dendritic arborization of adult-generated dentate gyrus neurons. At 2.5-20 μM, ISX-9 has been shown to dose-dependently trigger neurogenesis and block gliogenesis in adult rat hippocampal stem cells through a calcium-activated signaling pathway dependent on myocyte-enhancer factor 2-dependent gene expression.
Molecular exploration of ISX-9-induced regulation of neurogenesis (via FACS and microarray of SGZ stem and progenitor cells) suggested the involvement of the myocyte-enhancer family of proteins (Mef2).
In Vivo: ISX-9 (20 mg/kg; for 12 days; mice) treatment improves hippocampal function. ISX-9 enhances spatial memory ability in the Morris water maze test. ISX-9 enhances hippocampal neurogenesis and memory in vivo, and its effects are reliant on Mef2.
! For research use only. Not intended for any clinical use.
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