iPSC-Based Cardiovascular Disease Modeling

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Induced pluripotent stem cells (iPSC) can be cultured and differentiated into cardiomyocytes. Therefore, iPSC can be used for in vitro disease modeling and cell-based therapy strategies. Ace Therapeutics aims to provide iPSC model development services to help our clients conduct in-depth cardiovascular disease research.

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Applications of iPSC in Cardiovascular Disease Research

With iPSC-derived cardiomyocytes, it is possible to conduct cardiovascular disease research more comprehensive and detailed.

• Drug Screening
  iPSC-derived cardiomyocytes exert the electrophysiological properties of the developing heart and mimic the function of primary cardiac cells. This makes them ideal research models for drug screening and development applications.
• Disease Modeling
  iPSCs are derived from patients with specific diseases and reprogrammed into cells that retain the specific characteristics. iPSCs can be used for disease-specific modeling to provide disease-specific in vitro models for research.
• 3D Tissue Culture
  iPSC-derived cardiomyocytes can be used for 3D tissue culture, allowing for the development of in vitro culture systems to promote structural and functional maturation of cells in a more bionic way.

Fig. 1 Subtype differentiation of iPSCs and platforms to model diseases. (Funakoshi S. and Yoshida Y., 2021)

Ace Therapeutics provides iPSC-based modeling services for cardiovascular disease research. We have comprehensive gene editing and stem cell culture technology platforms that overcome many difficulties in iPSC culture and gene modification to help our customers explore disease mechanisms and develop effective new therapies. 

We provide iPSC modeling services for different application fields such as cardiovascular disease modeling, high-throughput drug screening, and stem cell-based therapy development. Additionally, we offer phenotype analysis and drug efficacy evaluation, striving to provide customers with comprehensive solutions for iPSC-based research.

Ace Therapeutics is a contract research organization dedicated to providing customized iPSC-based modeling services for cardiovascular disease research. If you are interested in our services, please do not hesitate to contact us.

1. Funakoshi, S.; Yoshida Y. Recent progress of iPSC technology in cardiac diseases. Arch Toxicol. 2021, 95(12):3633-3650.