An ideal pharmacokinetic profile is one of most important factors in the development of a drug candidate as a marketable drug. Ace Therapeutics has a in vitro pharmacokinetic technology platform that can provide clients with professional solutions for in vitro pharmacokinetic studies of cardiovascular drugs.
With the continuous improvement of the research level of new drugs, some new in vitro pharmacokinetic study tools are gradually mature. Using in vitro methods to study metabolic pathways and kinetic characteristics is more convenient, saves animals, and can obtain more information, such as analyzing metabolic patterns, kinetic parameters of metabolizing enzymes' effects on drugs, and the affinity of drugs and their metabolites for target molecules such as proteins and DNA. In vitro pharmacokinetic evaluation can be used to predict the in vivo metabolic mechanisms and metabolic characteristics of cardiovascular drugs and provide data for in vivo pharmacokinetic studies.
Fig. 1 Prevalent in vitro dissolution methods for nano drug delivery systems. (Gupta R, et al., 2021)
Ace Therapeutics can offer the following study services for in vitro pharmacokinetic studies of cardiovascular drugs.
Physicochemical property of drugs is a key issue that needs to be clarified in the early stage of drug development. We can provide comprehensive solutions for in vitro physicochemical property studies such as drug solubility, cell membrane permeability, and stability.
The cell membrane permeability and drug-transporter interactions may have an impact on the in vivo metabolism of a drug. We can provide cell membrane permeability and transporter studies of cardiovascular drugs to help our clients understand the in vitro metabolism of their drugs early in development.
Most drugs are metabolized sequentially in the liver by monophasic and biphasic metabolizing enzymes. We can provide in vitro metabolic stability studies of cardiovascular drugs to study the rate of drug biotransformation in liver microsomes and hepatocytes as a way of predicting the likelihood of drug metabolism in vivo.
When a drug activates or inhibits the hepatic P450 enzyme system, it may have a significant effect on the in vivo metabolism of other drugs. We can conduct studies on the effects of drugs on P450 enzymes, including inhibition, activation, or induction of metabolic enzymes.
Ace Therapeutics is a contract research organization specializing in drug research for cardiovascular diseases. We have a specialized pharmacokinetic research technology platform that can provide in vitro pharmacokinetic study services for cardiovascular drugs based on our clients' needs. If you are interested in our services, please don't hesitate to contact us.
Ace Therapeutics offers comprehensive solutions and R&D services to researchers worldwide to advance the field of cardiovascular diseases.
We do not provide medical care for patients.
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