ICA-121431
Cat. No: CDIA-0545
CAS. No.: 313254-51-2
Size: 5 mg
| Product Details |
| Formula |
C23H19N3O3S2 |
| Molecular Weight |
449.55 |
| Appearance |
Solid |
| Purity |
98.65% |
| Smiles String |
O=C(NC1=CC=C(S(NC2=NC=CS2)(=O)=O)C=C1)C(C3=CC=CC=C3)C4=CC=CC=C4 |
| Storage & Handling |
| Shipping |
Room temperature. |
| Storage Powder |
-20 °C/3 years, 4 °C/2 years |
Description
ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Nav) blocker, shows equipotent selectivity for human Nav1.1 and Nav1.3 subtypes with IC50 values of 13 nM and 23 nM, respectively. ICA-121431 shows less potent inhibition of Nav1.2 (IC50=240 nM) and 1,000 fold selectivity against Nav1.4, Nav1.6, and the TTX-resistant human Nav1.5 and Nav1.8 channels (IC50s >10 µM).
! For research use only. Not intended for any clinical use.
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