ICA-105574

Cat. No: CDIA-1858

CAS. No.: 316146-57-3

Size: 50 mg

Price: Inquiry

Product Details
Formula	C19H14N2O4
Molecular Weight	334.33
Smiles String	O=C(NC1=CC=C(OC2=CC=CC=C2)C=C1)C3=CC=CC([N+]([O-])=O)=C3

Storage & Handling
Shipping	Room temperature.
Storage	Please refer to the instruction manual.

Description

ICA-105574 is a potent and efficacious hERG channel activator. The primary mechanism by which ICA-105574 potentiates hERG channel activity is by removing hERG channel inactivation. ICA-105574 steeply potentiates current amplitudes more than 10-fold with an EC50 value of 0.5 +/- 0.1 μM and a Hill slope (n(H)) of 3.3 +/- 0.2.

! For research use only. Not intended for any clinical use.