Hyperlipoproteinemia, caused by disorders of lipid metabolism, is the origin of the formation of atherosclerosis. Ace Therapeutics aims to provide research outsourcing services, including animal models and drug discovery research, to advance basic research and drug development in hyperlipoproteinemia.
Neutral fats in the body, including triglycerides (TG), cholesterol (CH), phospholipids, glycolipids, and steroids, are collectively known as lipids. Abnormal deposition of lipids in blood vessels can cause atherosclerosis and secondary causes of coronary heart disease, cerebrovascular disease and peripheral vascular disease. Hyperlipoproteinemia is one of the major risk factors for cardiovascular disease, in which elevated TC, TG, LDL, VLDL, and reduced HDL are particularly important. Achieving the ideal level by regulating the lipid period is an important means of cardiovascular disease prevention and therapy.
Fig. 1 The process of cholesterol metabolism. (Benito-Vicente A, et al., 2018)
Hyperlipidemia is a chronic disease that requires long-term pharmacological therapy, so the development of long-acting and stable therapeutic agents has been a major trend for a long time. In recent years, many innovative targets and therapies have emerged, providing new perspectives for refined therapy strategies for dyslipidemia.
Overview of Novel Drugs for Hyperlipoproteinemia
| Drug Name | Drug Target | Original Organization | Drug Phase |
|---|---|---|---|
| Inclisiran | PCSK9 | Alnylam Pharmaceuticals, Inc. | Approved |
| Evinacumab-dgnb | ANGPTL3 | Regeneron Pharmaceuticals, Inc. | Approved |
| Beperminogene perplasmid | c-Met | AnGes, Inc. | Approved |
| Lerodalcibep | PCSK9 | LIB Therapeutics LLC | Phase 3 |
| MK-0616 | PCSK9 | Merck Sharp and Dohme Corp. | Phase 3 |
| Pelacarsen | Lipoprotein a | Ionis Pharmaceuticals, Inc. | Phase 3 |
| Obicetrapib | CETP | Mitsubishi Tanabe Pharma Corp. | Phase 3 |
Ace Therapeutics is able to provide clients with outsourcing services for disease model development and research technology, so as to facilitate basic research and the development of novel therapeutic approaches for hyperlipoproteinemia.
Research Models
Basic Research
Drug Development
We understand that constructing appropriate research models is the foundation of hypercholesterolemia research, so we are committed to providing professional animal model development services to meet our clients' research needs.
Transgenic Animal Model Development Services
To support animal studies of the pathogenic mechanisms of hypercholesterolemia, we can provide customized transgenic or knockout animal model development services, including but not limited to the following genes:
Genetically Engineered Mouse Models
We can provide the following high quality genetically engineered mice for hyperlipoproteinemia.
Cardiomyocyte Cell Lines
For in vitro research, we are able to provide our customers with a wide range of cardiomyocyte cell lines.
We aim to help our clients resolve difficulties encountered in hyperlipoproteinemia research and provide professional pathology and imaging study services.
Pathogenesis Research Services
Based on our professional multi-omics research platform, we can provide personalized research services to help clients explore the pathogenesis of hyperlipoproteinemia.
Pathology and Imaging Services
For animal studies of hyperlipoproteinemia, we can provide researchers with pathology and imaging study services for intuitive model validation and efficacy assessment, including but not limited to:
We can provide research and development services for hyperlipoproteinemia drug therapies, including but not limited to the following drug types and targets:
R&D Services by Drug Type
R&D Services by Target
Ace Therapeutics has been involved in cardiovascular disease research for many years and has accumulated extensive experience in hyperlipoproteinemia research. We aim to provide basic research and novel therapies discovery services for our clients. If you are interested in our services for hyperlipoproteinemia, please don't hesitate to contact us.
Ace Therapeutics offers comprehensive solutions and R&D services to researchers worldwide to advance the field of cardiovascular diseases.
We do not provide medical care for patients.
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