Hydroxy desmethyl bosentan
Online Inquiry
* Please note that all of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

Hydroxy desmethyl bosentan

Cat. No: CDIA-1355
CAS. No.: 253688-62-9
Synonyms: Ro 64-1056
Size: 50 mg
Price: Inquiry
Product Details
Formula C26H27N5O7S
Molecular Weight 553.59
Smiles String O=S(C1=CC=C(C(C)(C)CO)C=C1)(NC2=NC(C3=NC=CC=N3)=NC(OCCO)=C2OC4=CC=CC=C4O)=O
Storage & Handling
Shipping Room temperature.
Storage Please refer to the instruction manual.

Description

Hydroxy desmethyl Bosentan (Ro 64-105) is a Bosentan metabolism produced by the cytochrome P450 enzymes CYP2C9 and CYP3A4 in the liver. Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively. Bosentan can be used in treatment of pulmonary arterial hypertension.

! For research use only. Not intended for any clinical use.