Halofuginone

Product Details
Formula	C16H17BrClN3O3
Molecular Weight	414.68
Appearance	Solid
Purity	99.78%
Smiles String	O=C1N(CC(C[[email protected]@H]2NCCC[[email protected]]2O)=O)C=NC3=C1C=C(Cl)C(Br)=C3

Storage & Handling
Shipping	Room temperature.
Storage Powder	-20 °C/3 years, 4 °C/2 years

Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.

! For research use only. Not intended for any clinical use.