Halofuginone hydrobromide
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Halofuginone hydrobromide

Cat. No: CDIA-0278
CAS. No.: 64924-67-0
Synonyms: RU-19110 hydrobromide
Size: 1 mg
Price: Inquiry
Product Details
Formula C16H18Br2ClN3O3
Molecular Weight 495.59
Appearance Solid
Purity 99.55%
Smiles String O=C1N(CC(C[[email protected]@H]2NCCC[[email protected]]2O)=O)C=NC3=C1C=C(Cl)C(Br)=C3.Br
Storage & Handling
Shipping Room temperature.
Storage 4 °C, sealed storage, away from moisture *In solvent : -80 °C, 6 months; -20 °C, 1 month (sealed storage, away from moisture)

Description

Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.

! For research use only. Not intended for any clinical use.