Drug Delivery System Development Services for Cardiovascular Diseases

An ideal delivery system is essential for the efficacy of many novel therapies, such as nucleic acid-based and protein-based drugs. Ace Therapeutics' mission is to help clients develop better drug delivery systems for the treatment of cardiovascular diseases to speed up the process of drug development.

Overview of Drug Delivery for Cardiovascular Diseases

Targeted therapy is currently the focus of cardiovascular disease treatment, and current research on various delivery systems is dedicated to the effective delivery of therapeutic agents to their targets. In the development of novel cardiovascular drugs, designing an ideal drug delivery system is a high priority in the development of small molecule drugs, biologics, and RNA-based therapies. Biocompatible nanoparticles and biomaterial drug carriers are the main materials used in cardiovascular drug delivery systems.

Fig. 1 Advanced drug delivery micro- and nanosystems for CVDs. (Iravani S, and Varma RS, 2022)

Ace Therapeutics has an experienced research team that can design appropriate delivery systems for cardiovascular drugs.

Selection and Development of Drug Delivery Systems

We can choose the appropriate delivery system based on the characteristics and routes of administration for cardiovascular drugs.

• Oral Drug Delivery Systems
  We can design modified oral formulations such as tablets and capsules to optimize drug absorption and reduce the first-pass metabolism of cardiovascular drugs.
• Injectable Drug Delivery Systems
  We can design subcutaneous, intramuscular, or intravascular injectable drug delivery formulations that typically use liposomes and nanoparticles as the backbone structure of the delivery system.
• Implantable Drug Delivery Devices
  We can design stents and other devices that are implanted directly into the target cardiovascular site for long-term drug release.
• Transdermal Drug Delivery Systems
  We can design transdermal delivery systems such as patches or gels to deliver cardiovascular drugs through the skin.
• Inhalation Drug Delivery Systems
  We can design inhalation drug delivery systems for rapid systemic delivery by the pulmonary route via aerosols or inhalers.

In Vitro Evaluation of Drug Delivery Systems

• In Vitro Characterization of Drug Delivery Systems
  We can characterize drug delivery systems in vitro by determining their particle size, morphology, surface charge, drug encapsulation rate and release characteristics.
• In Vitro Stability Studies of Drug Delivery Systems
  We can evaluate the stability of drug-free vehicles as well as drug-loaded vehicles under different conditions.
• In Vitro Cytotoxicity Testing of Drug Delivery Systems
  We can test drug delivery systems in relevant cell cultures to assess efficacy, cytotoxicity and uptake by target cells.

In Vivo Evaluation of Drug Delivery Systems

We can evaluate the pharmacokinetic, pharmacodynamic, and toxicological properties of drug delivery systems using appropriate animal models of cardiovascular disease to determine the efficacy and safety of drug delivery systems.

Ace Therapeutics is a contract research organization that provides cardiovascular disease drug discovery and development services, and we offer drug delivery system development services based on our clients' individual needs. If you are interested in our services, please don't hesitate to contact us.

1. Iravani, S.; Varma, R.S. Advanced drug delivery micro- and nanosystems for cardiovascular diseases. Molecules. 2022, 27(18):5843.