Digitoxin

Product Details
Formula	C41H64O13
Molecular Weight	764.94
Appearance	Solid
Purity	99.36%
Smiles String	C[[email protected]]1O[[email protected]](O[[email protected]@H]2[[email protected]@H](C)O[[email protected]](O[[email protected]]3[[email protected]@H](O)C[[email protected]@](O[[email protected]@H]4C[[email protected]](CC[[email protected]]5([H])[[email protected]]6([H])CC[[email protected]@]7(C)[[email protected]]5(O)CC[[email protected]@H]7C(CO8)=CC8=O)([H])[[email protected]]6(C)CC4)([H])O[[email protected]@H]3C)([H])C[[email protected]@H]2O)([H])C[[email protected]](O)[[email protected]@H]1O

Storage & Handling
Shipping	Room temperature.
Storage Powder	-20 °C/3 years, 4 °C/2 years

Digitoxin is an effective Na+/K+-ATPase inhibitor, the EC50 value of Digitoxin is 0.78 μM. IC50 value: 0.78 μM (EC50) Target: Na+/K+-ATPase in vitro: Digitoxin shows a significantly cytotoxic effect in H1975 cells by causing G2 phase arrest, also remarkably activates 5' adenosine monophosphate-activated protein kinase (AMPK). Moreover, Digitoxin suppresses microtubule formation through decreasing α-tubulin. Digitoxin effectively depresses the growth of TKI-resistance NSCLC H1975 cells by inhibiting microtubule polymerization and inducing cell cycle arrest. Digitoxin has the highest cytotoxicity in H1975 cells, whose CC50 value was 0.19 ± 0.06 μM. Digitoxin-induced inhibition mechanism is likely due to causing G2/M cell cycle arrest in H1975 cells in dose dependent manners.

! For research use only. Not intended for any clinical use.