DI-1859

Cat. No: CDIA-1057

CAS. No.: 2247061-09-0

Size: 5 mg

Price: Inquiry

Product Details
Formula	C30H45N5O3S
Molecular Weight	555.78
Appearance	Solid
Purity	99.83%
Smiles String	CN(C)CC(C(NC[[email protected]](C1CCCCC1)NC([[email protected]@H](NC(CC)=O)CC(SC2=C3)=NC2=CC=C3C(C)C)=O)=O)=C

Storage & Handling
Shipping	Room temperature.
Storage Powder	-20 °C/3 years, 4 °C/2 years

Description

DI-1859 is a potent, selective and covalent inhibitor of DCN1. DI-1859 inhibits neddylation of cullin 3 in cells at low nanomolar concentrations. DI-1859 induces a robust increase of NRF2 protein, a CRL3 substrate, in mouse liver and effectively protects mice from acetaminophen-induced liver damage.

! For research use only. Not intended for any clinical use.