Development of Heart-on-a-Chip Models

Inquiry

In recent years, heart-on-a-chip has emerged as a powerful new tool to fill the translational gap from animal models to human diseases in cardiovascular disease research. Ace Therapeutics can provide customized heart-on-a-chip model development services to solve problems encountered by clients in cardiovascular disease research.

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Applications of Heart-on-a-Chip

As a novel in vitro platform that accurately reproduces physiological functions, organ-on-a-chip is a powerful tool for modeling complex diseases and preclinical development of new drugs. Heart-on-a-chip simulates the cardiovascular system dynamics, such as shear stress, transmural stress, mechanical stretching, and electrical stimulation, which is suitable for studying a variety of cardiovascular physiological phenomena and exploring drug effects. Currently, a variety of heart-on-a-chip models have been reported to be used in studies of myocardial ischemia, cardiac fibrosis and cardiotoxicity.

Fig. 1 Heart-on-chip devices can recapitulate cardiac functions in vitro. (Paloschi V, et al., 2021)

Ace Therapeutics can help customers develop heart-on-a-chip model for cardiovascular disease research, with the goal of providing valuable tools for the research and drug discovery of heart diseases.

Development of 3D Printed Heart-on-a-Chip

We can develop heart-on-a-chip models that can simulate the microstructure and function of the heart by introducing 3D printing technology. Our heart-on-a-chip models simulates the microenvironment of heart diseases in a chip and can be widely used in pathogenesis research and drug development.

• 3D Printing Materials
  Natural materials: alginate, collagen, fibrin, and gelatin
  Synthetic materials: custom printing materials such as polycaprolactone (PCL), and silicone
• 3D Printing Technologies
  • Micro-extrusion-based 3D Printing
  • 3D Inkjet Printing
  • Laser-assisted 3D Printing
  • Stereolithography (SLA) 3D Printing

Ace Therapeutics is a contract research organization dedicated to providing technical support and outsourcing services for cardiovascular disease research. We can develop customized heart-on-a-chip models to meet your specific research needs. If you are interested in our services, please don't hesitate to contact us.

1. Paloschi, V.; et al. Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases. Cardiovasc Res. 2021, 117(14):2742-2754.