CCG258747

Cat. No: CDIA-1182

CAS. No.: 2615910-00-2

Size: 50 mg

Price: Inquiry

Product Details
Formula	C28H27FN4O4
Molecular Weight	502.54
Appearance	Solid
Purity	99.17%
Smiles String	O=C(NCC1=NNC2=CC=CC=C12)C(C=C3[[email protected]@](CCNC4)([H])[[email protected]@H]4COC5=CC=C(OCO6)C6=C5)=C(C=C3)F

Storage & Handling
Shipping	Room temperature.
Storage	4 °C, sealed storage, away from moisture and light *In solvent : -80 °C, 6 months; -20 °C, 1 month (sealed storage, away from moisture and light)

Description

CCG258747 is a selective GRK2 inhibitor (IC50=18 nM) with high selectivity over GRK1, GRK5, PKA, and ROCK1 (518, 83, >5500, and >550–fold, respectively).CCG258747 also blocks the internalization of the µ-opioid receptor. G protein-coupled receptor (GPCR) kinases (GRKs) are attractive targets for the research of heart failure.

! For research use only. Not intended for any clinical use.