Candesartan cilexetil
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Candesartan cilexetil

Cat. No: CDIA-0378
CAS. No.: 145040-37-5
Synonyms: TCV-116
Size: 1 mg
Price: Inquiry
Product Details
Formula C33H34N6O6
Molecular Weight 610.66
Appearance Solid
Purity 99.92%
Smiles String O=C(C1=C2C(N=C(OCC)N2CC3=CC=C(C4=CC=CC=C4C5=NNN=N5)C=C3)=CC=C1)OC(OC(OC6CCCCC6)=O)C
Storage & Handling
Shipping Room temperature.
Storage Powder -20 °C/3 years, 4 °C/2 years

Description

Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. Target: Type-1 angiotensin II receptor Candesartan is generally well tolerated and significantly reduced cardiovascular deaths and hospital admissions for heart failure. Ejection fraction or treatment at baseline did not alter these effects . In rats, TCV-116 inhibited the pressor responses to Ang I, Ang II, and Ang III without an effect on the bradykinin (BK)-induced depressor response. In SHR, the antihypertensive effect of TCV-116 (10 mg/kg) was larger than the maximum antihypertensive effect of enalapril and was not intensified by combination with enalapril. TCV-116 is more effective than enalapril in reducing blood pressure in SHR and 1K, 1C-HR, and that the BK- and/or prostaglandin-potentiating effect of enalapril contributes little to its antihypertensive mechanism in SHR .

! For research use only. Not intended for any clinical use.