Candesartan cilexetil
Cat. No: CDIA-0378
CAS. No.: 145040-37-5
Synonyms: TCV-116
Size: 1 mg
Product Details |
Formula |
C33H34N6O6 |
Molecular Weight |
610.66 |
Appearance |
Solid |
Purity |
99.92% |
Smiles String |
O=C(C1=C2C(N=C(OCC)N2CC3=CC=C(C4=CC=CC=C4C5=NNN=N5)C=C3)=CC=C1)OC(OC(OC6CCCCC6)=O)C |
Storage & Handling |
Shipping |
Room temperature. |
Storage Powder |
-20 °C/3 years, 4 °C/2 years |
Description
Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.
Target: Type-1 angiotensin II receptor
Candesartan is generally well tolerated and significantly reduced cardiovascular deaths and hospital admissions for heart failure. Ejection fraction or treatment at baseline did not alter these effects . In rats, TCV-116 inhibited the pressor responses to Ang I, Ang II, and Ang III without an effect on the bradykinin (BK)-induced depressor response. In SHR, the antihypertensive effect of TCV-116 (10 mg/kg) was larger than the maximum antihypertensive effect of enalapril and was not intensified by combination with enalapril. TCV-116 is more effective than enalapril in reducing blood pressure in SHR and 1K, 1C-HR, and that the BK- and/or prostaglandin-potentiating effect of enalapril contributes little to its antihypertensive mechanism in SHR .
! For research use only. Not intended for any clinical use.
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