Biocompatibility Evaluation Services for Cardiovascular Implant Materials

As a class of medical devices that come into direct contact with blood, cardiovascular implants must be well-biocompatible to ensure post-implantation safety. Ace Therapeutics is able to provide biocompatibility evaluation services for the development of different types of cardiovascular implant materials.

Overview of Biocompatibility for Cardiovascular Implants

Cardiovascular implant biocompatibility evaluation mainly includes two categories: hemocompatibility and histocompatibility evaluation. The hemocompatibility evaluation focuses on the interaction between the implant material and the blood, while the histocompatibility evaluation mainly examines the effects of the implant on the tissues and organs of the cardiovascular system.

Fig. 1 The role of allergic inflammation in adverse reactions after stent implantation. (Pelliccia F, et al., 2023)

Ace Therapeutics has extensive experience in cardiovascular disease research and is able to provide complete biocompatibility evaluation services for our clients' cardiovascular implant studies, which will assist in the development of cardiovascular implants.

Blood Compatibility Tests for Cardiovascular Implant Materials

Since cardiovascular implants come into direct contact with the bloodstream, the blood compatibility of cardiovascular implant materials is a top priority for biocompatibility studies. We are able to provide the following blood compatibility testing services:

• In Vitro Hemolysis Tests
• Thrombosis Tests
• Coagulation Tests
• Platelet Adhesion Tests
• Assays for Complement Activation

Cytotoxicity Tests for Cardiovascular Implant Materials

We can evaluate the cytotoxicity of cardiovascular implant materials by using cell culture medium as the extraction medium and subjecting the extracts of cardiovascular implant materials to cell proliferation toxicity tests.

Pyrogen Tests for Cardiovascular Implant Materials

We are able to provide pyrogen detection test services for cardiovascular implant materials. Specifically, we inject extracts of cardiovascular implant materials into a vein at the ear margin of a rabbit, measure the change in body temperature of the rabbit, and evaluate whether there is a possibility that the cardiac stent or material induces fever in the body.

Irritation and Sensitization Tests for Cardiovascular Implant Materials

We are able to provide test studies to evaluate the irritation and sensitization of cardiovascular implant materials, including skin and mucous membrane irritation, eye irritation, and evaluation of delayed hypersensitivity reactions.

Implantation Response Tests for Cardiovascular Implant Materials

We can provide in vivo animal implantation testing services to evaluate the effects of cardiovascular implantation on the animal's body through imaging and histopathology.

Ace Therapeutics has extensive research experience in the field of cardiovascular implants. We are dedicated to providing biocompatibility evaluation services for various types of cardiovascular implant materials to assist our clients in advancing their research. If you are interested in our services for biocompatibility evaluation, please do not hesitate to contact us.

1. Pelliccia, F.; et al. In-stent restenosis after percutaneous coronary intervention: emerging knowledge on biological pathways. Eur Heart J Open. 2023, 3(5): oead083.