Avatrombopag hydrochloride

Cat. No: CDIA-0554

CAS. No.: 570403-17-7

Synonyms: AKR-501 hydrochloride; E5501 hydrochloride; YM477 hydrochloride

Size: 5 mg

Price: Inquiry

Product Details
Formula	C29H35Cl3N6O3S2
Molecular Weight	686.12
Appearance	Solid
Purity	98.53%
Smiles String	O=C(C1CCN(C2=NC=C(C(NC3=NC(C4=CC(Cl)=CS4)=C(N5CCN(C6CCCCC6)CC5)S3)=O)C=C2Cl)CC1)O.Cl

Storage & Handling
Shipping	Room temperature.
Storage	4 °C, sealed storage, away from moisture *In solvent : -80 °C, 6 months; -20 °C, 1 month (sealed storage, away from moisture)

Description

Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC50=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag hydrochloride is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A.

! For research use only. Not intended for any clinical use.